MCAM INHIBITORS

摘要

The present invention relates to polypeptides inhibiting the function of MCA M in naturally occurring tumor cells and their use, and the use of other molecules inhibiting MCAM function, for the treatment of cancers, particular ly for reducing the invasiveness, proliferation, adhesion and/or the metastatic potential of specific cancer cells. Furthermore, a method is provided that allows determining whether a naturally occurring tumor cell depends on functional MCAM for its invasiveness, adhesiveness, proliferation and/or its metastatic potential. Finally, a method is provided that allows identifying an antibody or an antibody fragment capable of inhibiting invasiveness, proliferation or adhesiveness of tumor cells.