发明名称 |
3-GUANIDINOCARBONYL-1-HETEROARYL-INDOLE DERIVATIVES, PREPARATION PROCESS, THEIR USE AS MEDICAMENTS, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM |
摘要 |
The present invention relates to 3-guanidinocarbonyl-1-heteroaryl-indole derivatives of the formula (I) in which R1 to R3 and Ar have the meanings stated in the claims. The inventive compounds are suitable for example as antiarrhythmic medicaments with a cardioprotective component for infarction prophylaxis and infarction treatment and for the treatment of angina pectori s. They also inhibit in a preventive manner the pathophysiological processes associated with the development of ischemia-induced damage, in particular in the triggering of ischemia-induced cardiac arrhythmias and of heart failure.
|
申请公布号 |
CA2492421(A1) |
申请公布日期 |
2004.01.22 |
申请号 |
CA20032492421 |
申请日期 |
2003.07.02 |
申请人 |
AVENTIS PHARMA DEUTSCHLAND GMBH |
发明人 |
KLEEMANN, HEINZ-WERNER;CARRY, JEAN-CHRISTOPHE;DESMAZEAU, PASCAL;MIGNANI, SERGE;GENEVOIS-BORELLA, ARIELLE;BOUQUEREL, JEAN;RONAN, BAPTISTE |
分类号 |
A61P3/00;A61P7/00;A61P9/00;A61P35/00;A61P37/06;C07D401/04;C07D403/04;C07D487/04;(IPC1-7):C07D401/04;A61K31/404;A61K31/470 |
主分类号 |
A61P3/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|