MODULATION OF CYTOCHROME P450 REDUCTASE ACTIVITY

摘要

A non-human transgenic animal, tissues and/or cells derived therefrom comprising cells with a conditional deletion of cytochrome P450 reductase gene, so that at least some cells have depleted or ablated cytochrome P450 reductase (CPR) expression. The invention also provides methods of producing such animals and uses therefor in both in vivo and in vitro screens particularly for use in product development, disposition and/or toxicity studies and/or rationalised product design or product discovery.