OXAZOLE DERIVATIVES AND THEIR USE AS INSULIN SENSITIZERS

摘要

Compound of formula (I): and pharmaceutically acceptable salts and esters thereof, wherein R<1> is aryl; R<2> is hydrogen, alkyl or cycloalkyl; R<3> is hydrogen, alkyl, aralkyl, aryl, alkylcarbonyl, arylcarbonyl, alkyl-S(O)2- or aryl-S(O)2- ; R<4> is aralkyl; R<5>, R<6>, R<7> and R<8> are independently selected from hydrogen, alkyl or cycloalkyl; and n is 1,2,3,4 or 5, are useful as insulin sensititers, particularly PPAR activators.