| 摘要 |
A method for treating cancer by administering an effective amount of a combination of a first expression vector comprising a type 2 (Th2) cytokines coding sequence and a second expression vector comprising a type 1 (TH1) cytokines coding sequence, in a mammalian patient, wherein the type 2 cytokines coding sequence is hIL-10 and the type 1 cytokines coding sequence is hIL-12. It is provided an anti-tumor cell vaccine comprising cells transfected with the first expression vector and cells transfected with the second expression vectors. Said cells could be autologous cells as tumor cells, tumor infiltrating lymphocytes, LAK cells, endothelium precursor cells, fibroblasts, keratinocites and dendritic cells, wherein the cells delivery an amount of hIL-12 and an amount of hIL-10. Further, the method comprising administering an effective amount of an expression vector comprising a first type 2 (Th2) cytokines coding sequence and a second type 1 (TH1) cytokines coding sequence as IL-10 and IL-12 coding sequences. |
