| 摘要 |
The invention relates to substituted pyrrole Mannich bases of general formula (I), wherein R<SUP>1</SUP>=H, a C<SUB>1-10</SUB>-alkyl-, aryl, a heteroaryl- or an aryl, heteroaryl-, CN, Br-, Cl or OH radical bound by a C<SUB>1-6 </SUB>alkylene group, R<SUP>2</SUP>=CH(R<SUP>4</SUP>)N(R<SUP>5</SUP>)(R<SUP>6</SUP>), R3, R3', R3'' identically or individually represent H, F, Cl, Br, CF<SUB>3</SUB>, CN, NO<SUB>2</SUB>, SO<SUB>2</SUB>NH<SUB>2</SUB>, NHR<SUP>7</SUP>, SR<SUP>8</SUP>, OR<SUP>9</SUP>, CO(OR<SUP>10</SUP>), CH<SUP>2</SUP>CO(OR<SUP>11</SUP>), COR<SUP>15</SUP>, a C<SUB>1-10</SUB>-alkyl-, aryl-, heteroaryl-aryl radical or a heteroalkyl radical bound by a C<SUB>1-6 </SUB>alkylene group, R<SUP>4</SUP>=an unsubstituted phenyl radical or a phenyl radical substituted at least with C<SUB>1-4 </SUB>alkyl, C<SUB>1-3</SUB>-alkoxy-, halogen-, a method for the production of the above-mentioned compounds, medicaments containing said compounds, and the use of said compounds in the production of medicaments. Said active ingredients are particularly suitable for pain therapy, and for treating inflammatory and allergic reactions, drug or alcohol abuse, diarrhoea, gastritis, ulcers, cardiovascular diseases, urinary incontinence, depressions, states of shock, migranes, narcolepsy, overweight, asthma, glaucoma, hyperkinetic syndrome, lack of drive, bulimia, anorexia, catalepsia, anxiolysis increasing vigilance and/or increasing libido. |
