COMPOSITIONS AND METHOD FOR ENHANCED MUCOSAL DELIVERY OF INTERFERON BETA

摘要

Compositions and methods are provided for intranasal delivery of interferon-beta yielding improved pharmacokinetic and pharmacodynamic results. In certain aspects of the invention, the interferon-beta is delivered to the intranasal mucosa along with one or more intranasal delivery-enhancing agent(s) to yield substantially increased absorption and/or bioavailability of the interferon-beta and/or a substantially decreased time to maximal concentration of interferon-beta in a tissue of a subject as compared to controls where the interferon-beta is administered to the same intranasal site alone or formulated according to previously disclosed reports. The enhancement of intranasal delivery of interferon-beta according to the methods and compositions of the present invention allows for the effective pharmaceutical use of these agents to treat a variety of diseases and conditions in mammalian subjects.