Non-human mammal mutant for expression of the alpha6 subunit of the nicotinic acetylcholine receptor, and use for screening substances that can interact with said receptor

摘要

The invention concerns a non-human mammal carrying a mutation in the gene coding for the alpha6 subunit of the nicotinic acetylcholine receptor (nAChR), said mutation preventing expression of said nAChR alpha6 subunit in a functional form in the mammal. The invention also concerns synaptosome preparations obtained from said animals and cell cultures obtained by mutation of the alpha6 subunit as defined above.