ADENOVIRUS VECTORS FOR IMMUNOTHERAPY

摘要

The present invention provides compositions, methods and kits comprising viral vectors that may be used for performing immunotherapy. In particular, the present invention provides viral vectors having subgroup B adenoviral capsid fibers that are configured to express a transgene sequence in antigen presenting cells (e.g. dendritic cells) with a high transduction efficiency. Preferably, the transgene sequence is a retrogen cassette and the adenoviral capsid fibers are Ad11 fibers.