SPIROSUBSTITUTED PIPERIDINES AS SELECTIVE MELANIN CONCENTRATING HORMONE RECEPTOR ANTAGONISTS FOR THE TREATMENT OF OBESITY

摘要

The present invention discloses compounds according to formula which are nov el antagonists for melanin-concentrating hormone (MCH), as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such MCH antagonists as well as metho ds of using them to treat obesity, metabolic disorders, eating disorders such a s hyperphagia, and diabetes.