METHODS AND COMPOSITIONS FOR INHIBITION OF MULTI-DRUG RESISTANCE BY HYALURONAN OLIGOMERS

摘要

Pharmaceutical compositions and methods for sensitizing multi-drug resistant cancer or radiation resistant cancer cells to chemotherapeutic agents are provided. Compositions include ligands of hyaluronan receptors, including glycosaminoglycans such as hyaluronan oligomers and derivatives of these oligomers, hyaluronan binding proteins, and antibodies specific for hyaluron an receptors.