BENZO(5,6)CYCLOHEPTAPYRIDINE CYCLIC UREAS AND LACTAMS USEFULAS FARNESYL PROTEIN TRANSFERASE INHIBITORS

摘要

Compounds of formula (I) useful for inhibiting Ras function and therefore inhibiting or treating the abnormal growth of cells are disclosed, or a pharmaceutically acceptable salt or solvate thereof, wherein: R and R2 are halo; R1 and R3 are H and halo, provided that at least one is H; W is N, CH, or C when the double bond is present at the C-11 position; R4 is -(CH2)n-R5 or (II); R5 is (III); R6 is R5 or (IV); Z1 and Z2 are indepen dently selected from the group consisting of =O and =S; n is 1-6; and n1 is 0 or 1.