发明名称 Process for the preparation of an dioxane acetic acid ester
摘要 <p>Process for the preparation of an ester of formula (1), wherein R&lt;1&gt; represents a leaving group, CN, OH or a COOR&lt;5&gt; group, R&lt;3&gt; and R&lt;4&gt; each independently represent a 1-3 C alkyl group, and R&lt;2&gt; and R&lt;6&gt; each independently represent an ester group, wherein the corresponding salt with formula (2), wherein M represents H or an alkali (earth) metal in an inert solvent is contacted with an acid chloride forming agent to form the corresponding acid chloride, and the acid chloride is contacted with an alcohol with formula R&lt;2&gt;OH in the presence of N-methyl-morpholine. Preferably M represents an alkali metal, and R&lt;2&gt; represents an alkyl group, particularly a t.-butyl group. &lt;CHEM&gt; &lt;CHEM&gt;</p>
申请公布号 EP1375493(A1) 申请公布日期 2004.01.02
申请号 EP20020100715 申请日期 2002.06.17
申请人 ASTRAZENECA UK LIMITED 发明人 BAKEL VAN, HERMANUS CAROLUS CATHARINA KAREL;CALLANT, DOMINIQUE MONIQUE CHARLES;KOOISTRA, JACOB HERMANUS MATTHEUS HERO;MAAS, PETER JOHANNES DOMINICUS
分类号 C07D319/06;C07B53/00;C07B61/00;(IPC1-7):C07D319/06 主分类号 C07D319/06
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