发明名称 |
DIAGNOSTIC AND THERAPEUTIC USE OF RAS-GTPASE-ACTIVATING SH3-DOMAIN-BINDING PROTEIN 2 (G3BP2) FOR NEURODEGENERATIVE DISEASES |
摘要 |
The present invention discloses the differential expression of the G3BP2 gene in specific brain regions of Alzheimer's disease patients. Based on this finding, this invention provides a method for diagnosing or prognosticating a neurodegenerative disease, in particular Alzheimer's disease, in a subject, or for determining whether a subject is at increased risk of developing such a disease. Furthermore, this invention provides therapeutic and prophylactic methods for treating or preventing Alzheimer's disease and related neurodegenerative disorders using the G3BP2 gene and its corresponding gene products. A method of screening for modulating agents of neuro-degenerative diseases is also disclosed. |
申请公布号 |
WO2004001422(A2) |
申请公布日期 |
2003.12.31 |
申请号 |
WO2003EP06521 |
申请日期 |
2003.06.20 |
申请人 |
EVOTEC NEUROSCIENCES GMBH;VON DER KAMMER, HEINZ;POHLNER, JOHANNES |
发明人 |
VON DER KAMMER, HEINZ;POHLNER, JOHANNES |
分类号 |
A01K67/027;C07K14/47;C12N15/00;G01N33/68 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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