发明名称 |
NOVEL KCNQ POLYPEPTIDES, MODULATORS THEREOF, AND THEIR USES IN THE TREATMENT OF MENTAL DISORDERS |
摘要 |
The invention encompasses polypeptides and polynucleotides of three novel bipolar disorder-associated potassium channel polypeptides, KCNQ2-15bx, KCNQ2-15by and KCNQ2-15bz. The invention further relates to the use of potassium channels comprising KCNQ2 subunits for screening for modulators thereof, the use of these modulators for treating mental disorders such as bipolar disorder, schizophrenia and depression, and drugs comprising these modulators. The invention also discloses biallelic markers located in the KCNQ2 gene and their use for diagnosing mental disorders. |
申请公布号 |
WO2004000875(A2) |
申请公布日期 |
2003.12.31 |
申请号 |
WO2003EP50246 |
申请日期 |
2003.06.20 |
申请人 |
GENSET SA;CAVAREC, LAURENT;CHUMAKOV, ILYA;DESTENAVES, BENOIT;GONTHIER, CATHERINE;ELIAS, ISABELLE |
发明人 |
CAVAREC, LAURENT;CHUMAKOV, ILYA;DESTENAVES, BENOIT;GONTHIER, CATHERINE;ELIAS, ISABELLE |
分类号 |
G01N33/50;A61K38/00;A61K38/46;A61K45/00;A61K48/00;A61P25/00;A61P25/18;A61P25/24;A61P43/00;C07K14/47;C07K14/705;C07K19/00;C12N9/16;C12N15/09;C12N15/12;C12Q1/02;C12Q1/42;C12Q1/68;G01N33/15;G01N33/573;G01N33/68 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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