发明名称 |
Screening and therapeutic methods for treating circadian rhythm disorders |
摘要 |
The invention provides a method for screening for a compound for modulating circadian rhythm. The method involves (a) providing a compound that is a Prokineticin 2 (PK2) receptor antagonist or agonist; and (b) determining the ability of the compound to modulate one or more indicia of circadian rhythm function, wherein a compound that modulates one or more indicia of circadian rhythm function is identified as a compound for modulating circadian rhythm. The invention also provides a mouse PK2 receptor nucleic acid, polypeptide and related compositions. Further provided is a method for modulating circadian rhythm of an animal, which involves administering an effective amount of a PK2 receptor antagonist or agonist to an animal. Also provided is an isolated nucleic acid comprising a PK2 gene promoter operatively linked to a heterologous nucleotide sequence.
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申请公布号 |
US2003235535(A1) |
申请公布日期 |
2003.12.25 |
申请号 |
US20030417426 |
申请日期 |
2003.04.15 |
申请人 |
ZHOU QUN-YONG;BULLOCK CLAYTON M. |
发明人 |
ZHOU QUN-YONG;BULLOCK CLAYTON M. |
分类号 |
G01N33/50;A61K38/00;A61K45/00;A61K48/00;A61K49/00;A61P25/02;A61P25/20;A61P43/00;C07K14/47;C07K14/705;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12Q1/02;G01N33/15;G01N33/543;G01N33/566;(IPC1-7):A61K49/00 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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地址 |
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