Certain phenyl or pyridyl-propanol-amines containing alkyl-nitrate moieties

摘要

A compound represented by the following formula <IMAGE> wherein A represents a direct bond or the bond -0-CH2-, B represents a C1-C11 alkylene group bonded to a carbon atom of the aromatic ring D either directly or through -O-, -S-, -SO- or -NH-, W represents a carbon or nitrogen atom, R1 represents a C3-C7 alkyl group, a hydroxy-C1-C6 alkyl group, or a phenyl- or diphenyl-alkyl group with the alkyl group having 1 to 4 carbon atoms, R2 represents a member selected from the group consisting of hydrogen, halogen, OH, C1-C4 alkyl, NO2, C1-C4 alkoxy, acetyl, allyloxy, carbamoyl and sulfamoyl, and when two or more R2 groups exist, they may be identical or different, and n represents 1, 2 or 3 and m represents 1 or 2, provided that n+m>/=4; and an acid addition salt thereof; a process for producing the same; and a pharmaceutical composition comprising aforesaid compound.