PROCESS FOR THE PRODUCTION OF FLUTICASONE PROPIONATE, IN PARTICULAR OF POLYMORPHIC FORM 1

摘要

A process for preparing fluticasone propionate as crystalline polymorphic Form 1 which comprises reacting a compound of formula (II)or a salt thereof with a compound of formula LCH2F wherein L represents leaving group optionally in the presence of a phase transfer catalyst, a water-immiscible non-solvating organic liquid solvent and water is described.