COMBINATION OF PDE-V INHIBITORS AND NK1 ANTAGONISTS FOR THE TREATMENT OF DEPRESSION
摘要
The present invention relates to a method of treating depression or anxiety in a mammal, including a human, by administering to the mammal a CNS-penetrant NK-1 receptor antagonist (e.g., a substance P receptor antagonist) in combination with a PDE IV inhibitor. It also relates to pharmaceutical compositions containing a pharmaceutically acceptable carrier, a CNS-penetrant NK-1 receptor antagonist and a PDE IV inhibitor.
申请公布号
WO03105815(A1)
申请公布日期
2003.12.24
申请号
WO2003IB02524
申请日期
2003.06.05
申请人
PFIZER PRODUCTS INC.;SOBOLOV-JAYNES, SUSAN, BETH;SCHMIDT, CHRISTOPHER, JOSEPH;LEBEL, LORRAINE, ANN
发明人
SOBOLOV-JAYNES, SUSAN, BETH;SCHMIDT, CHRISTOPHER, JOSEPH;LEBEL, LORRAINE, ANN