Fused ring heteroaryl and heterocyclic compounds which inhibit leukocyte adhesion mediated by VLA-4

摘要

Disclosed herein are compounds that bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. These compounds can also be USED for the treatment of inflammatory brain diseases such as multiple sclerosis.