发明名称 |
RECOMBINANT DRUG-SENSITIVE VACCINIA VIRUS AS SMALLPOX VACCINE |
摘要 |
The present invention provides recombinant poxviruses, such as vaccinia virus, that contain an integrated exogenous sequence, such as a foreign gene, encoding a prodrug converting polypeptide that can convert a prodrug to a drug that prevents virus replication or is otherwise toxic to the virus. The recombinant poxviruses can be suitable for use as vaccines. The invention also provides, among other things, methods of inhibiting virus replication, methods of vaccination and methods of treating vaccinated subjects showing signs or otherwise at risk for of vaccination-induced disease. |
申请公布号 |
WO03078640(A3) |
申请公布日期 |
2003.12.18 |
申请号 |
WO2003EP02696 |
申请日期 |
2003.03.14 |
申请人 |
BAXTER INTERNATIONAL INC.;BAXTER HEALTHCARE S.A.;FALKNER, FALKO-GUENTER;HOLZER, GEORG;COULIBALY, SOGUE;MAYRHOFER, JOSEF |
发明人 |
FALKNER, FALKO-GUENTER;HOLZER, GEORG;COULIBALY, SOGUE;MAYRHOFER, JOSEF |
分类号 |
A61K39/00;A61K39/275;C12N9/12;C12N15/863 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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