Ligands for G protein coupled receptor GPR7 and GPR8 and uses thereof

摘要

The present invention is related to the identification of a family of polypeptide ligands that bind both the GPR7 and GPR8 G-protein coupled receptors, and to their use in screening methods for the identification of modulators of GPR7/8 receptor function and for diagnostic and therapeutic applications. The invention further relates to kits which use these orphan G protein coupled receptors and their ligands to identify agonist and antagonist compounds applicable to the diagnosis, prevention and/or treatment of diseases and disorders related to GPR7/8 receptor function or dysfunction.