发明名称 |
SUBSTITUTED HEXAHYDROPYRROLO[1,2-A]PYRAZINES, OCTAHYDROPYRIDO[1,2-A]PYRAZINES AND DECAHYDROPYRAZINO[1,2-A]AZEPINES |
摘要 |
Novel substituted hexahydropyrrolo[1,2-a]pyrazines, octahydropyrido[1,2-a]-pyrazines and decahydropyrazino[1,2-a]azepines, use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds, and a method of treatment employing these compounds and compositions. The compounds show a high and selective binding affinity to the histamine H3 receptor indicating histamine H3 receptor antagonistic, inverse agonistic activity. As a result, the compounds are useful for the treatment of diseases and disorders related to the histamine H3 receptor.
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申请公布号 |
WO03104235(A1) |
申请公布日期 |
2003.12.18 |
申请号 |
WO2003DK00329 |
申请日期 |
2003.05.19 |
申请人 |
NOVO NORDISK A/S |
发明人 |
PESCHE, BERND;HOHLWEG, ROLF |
分类号 |
A61K31/437;A61K31/4375;A61K31/519;A61P1/04;A61P3/04;A61P3/10;A61P9/10;A61P9/12;A61P19/02;A61P25/26;A61P25/28;A61P35/00;A61P37/08;A61P43/00;C07D471/04;C07D487/04;C07K5/06;(IPC1-7):C07D487/04 |
主分类号 |
A61K31/437 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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