MODULATORS OF RHO C ACTIVITY

摘要

Compounds of formula 1 modulate the activity of Rho C: (Formula I) wherein R1 is H, lower alkyl, aralkyl, aryl-lower alkenyl, or (CH2)nCH(R7)NR8R9, where n is 0-6 inclusive, R7 is H, lower alkyl, aryl, or aralkyl, R8 is H, lower alkyl, cyclo-alkyl, aryl, or aralkyl, and R9 is R, RCO-, ROCO-, or RNHCO-, where R is lower alkyl, cycloalkyl, aryl, or aralkyl, wherein aryl and aralkyl are substituted with 0-3 substituents selected from the group consisting of lower alkyl, halo, nitro, -OH, trifluoromethyl, or lower alkoxy; R2 is lower alkyl, aryl, aralkyl, or (CHR10)m-(CO)-R11, wherein m is 0-4, R10 is H or lower alkyl, and R11 is lower alkyl, cycloalkyl, aryl, or aralkyl, wherein aryl and aralkyl are substituted with 0-3 substituents selected from the group consisting of lower alkyl, halo, nitro, -OH, trifluoromethyl, or lower alkoxy; R3, R4, R5 and R6 are each independtly H, lower alkyl, halo, nitro, OH, lowe alkoxy, NH2, lower alkylamino, di(lower alkylamino), trifluoromethyl, or SH; or a pharmaceutically acceptable salt thereof.