发明名称 |
Neisserial vaccine free of immunologically functional PIII or class 4 proteins |
摘要 |
This invention relates to mutants of Neisseria useful for vaccine preparation. Specifically this invention relates to mutants of Neisseria containing mutations in a major outer membrane protein gene such that no immunologically functional polypeptides encoded by said gene are produced. More specifically, the invention relates to a mutant strain of Neisseria gonorrhoeae having a mutation of the PIII gene and to vaccines derived therefrom.
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申请公布号 |
US6664094(B1) |
申请公布日期 |
2003.12.16 |
申请号 |
US19940309620 |
申请日期 |
1994.09.21 |
申请人 |
THE ROCKEFELLER UNIVERSITY |
发明人 |
GOTSCHLICH EMIL CLAUS;WETZLER LEE MARK;BLAKE MILAN SCOTT;KOOMEY JOHN MICHAEL |
分类号 |
A61K39/00;A61K39/095;C07K14/22;C12N15/00;C12N15/31;(IPC1-7):C12N1/00 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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