| 摘要 |
<p>An intravenous composition that realizes sustained disintegration in place of fine particles of fat so as to exert satisfactory sustained-release effect and that is excellent in the ratio of inclusion of fat-soluble drug and exerts sustained-release effect at lesions; a process for producing the same; and preparations thereof. The intravenous composition comprises prostanoid or steroid enclosed in fine particles of polylactic acid/glycolic acid copolymer or polylactic acid, the fine particles of polylactic acid/glycolic acid copolymer or polylactic acid having lecithin or a similar surfactant adsorbed on the surface thereof. In particular, the process for producing the intravenous composition comprises dissolving an esterified prostanoic acid or esterified steroid and polylactic acid/glycolic acid copolymer or polylactic acid in, for example, an organic solvent such as dichloromethane or dimethyl sulfoxide and performing emulsification in water in the presence of lecithin or a similar surfactant capable of forming a diameter of 50 to 500 nm by means of an ultrasonic generator or Polytron agitator.</p> |
