发明名称 |
Short fragment homologous replacement to provide BSE resistant cattle |
摘要 |
A method for generating cattle resistant to Bovine Spongioform Encephalopathy through targeted alterations in the PrP gene is disclosed. The PrP gene of a cultured cells is altered to prevent its translation or to encode a dominant disease-resistant form of the protein, and the nucleus of the altered cell is used to clone a founder animal. In one embodiment, a single-stranded DNA fragment containing the alteration is used in single-stranded short fragment homologous replacement to alter the PrP gene.
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申请公布号 |
US2003229910(A1) |
申请公布日期 |
2003.12.11 |
申请号 |
US20030417964 |
申请日期 |
2003.04.17 |
申请人 |
METZ RICHARD;BLAESE R. MICHAEL |
发明人 |
METZ RICHARD;BLAESE R. MICHAEL |
分类号 |
A01K67/027;A61K48/00;C12N;C12N15/09;C12N15/85;C12N15/877;C12Q1/68;(IPC1-7):A01K67/027 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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