发明名称 |
Methods for evaluating therapies and predicting clinical outcome related to coronary conditions |
摘要 |
A method for predicting the clinical outcome for a patient after the patient has received therapy for an acute coronary syndrome such as myocardial infarction comprises: (a) optionally, but preferably, detecting a first variable comprising a serum creatine kinase-MB release curve area in the patient after initiation of said therapy; (b) detecting a second variable comprising a serum creatine kinase-MB release curve maxima in the patient after initiation of said therapy; then (c) optionally, but preferably, detecting a third variable comprising the slope of the descending portion of the serum creatine kinase-MB release curve after initiation of said therapy (wherein a steep slope for said descending portion is a more favorable indicator of clinical outcome than a shallow slope); and (d) generating a prediction of clinical outcome for said patient from the variables collected above. The method is useful in conjunction with established therapies such as thrombolytic therapy, and is particularly useful as a surrogate end point in clinical trials of new potential therapies.
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申请公布号 |
US6662114(B1) |
申请公布日期 |
2003.12.09 |
申请号 |
US20000642905 |
申请日期 |
2000.08.21 |
申请人 |
DUKE UNIVERSITY;UNIVERSITY OF MARYLAND |
发明人 |
CHRISTENSON ROBERT H.;DUH SHOW-HONG;VOLLMER ROBIN T.;OHMAN E. MAGNUS;THOMPSON TREVOR D.;NEWBY L. KRISTIN;CALIFF ROBERT M. |
分类号 |
C12Q1/50;(IPC1-7):G01N33/48;C12Q1/00;C12Q1/48;G06G7/48 |
主分类号 |
C12Q1/50 |
代理机构 |
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