发明名称 |
NOVEL VITAMIN D ANALOGUES |
摘要 |
Novel trienes have been provided which have antiinflammatory and immunomodulating effects. Such trienes have the Formula I (See Figure I) in which formula Q is -CH2-, -CH=CH- or -C .ident. C-; U is a C1-C6 alkylene ; R1 is hydrogen, a C1-C4 alkyl or YR', in which Y stands for the radicals -SO - or -SO2-, and R' stands for a C1-C4 alkyl; R2 and R3 are independently hydrogen or C1-C4 alkyl, and additionally R2 and R3, when taken together with the starre d carbon atom, may form a C3-C6 carbocyclic ring; Z is hydrogen or hydroxy; and prodrugs of the compound of Formula I in which at least one of the hydroxy groups are masked as groups which can be reconverted to hydroxy groups in vivo.
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申请公布号 |
CA2140247(C) |
申请公布日期 |
2003.12.09 |
申请号 |
CA19932140247 |
申请日期 |
1993.09.27 |
申请人 |
LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIE |
发明人 |
HANSEN, KAI;BRETTING, CLAUS AAGE SVENSGAARD |
分类号 |
A61K31/59;A61K31/593;A61P3/08;A61P9/12;A61P11/00;A61P17/00;A61P29/00;A61P35/00;A61P37/00;A61P43/00;C07C401/00;(IPC1-7):C07C401/00 |
主分类号 |
A61K31/59 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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