OXOPHENYL-CYCLOHEXYL-PROPANOLAMINE DERIVATIVES, PRODUCTION AND USE THEREOF IN THERAPEUTICS

摘要

The invention relates to compounds of general formula (I) wherein R1 represents H, a (C1-C4) alkyl, -CO(C1-C4)alkyl , (C1-C4)alkyl-phenyl or -CO-phenyl group, whereby phenyl can optionally be substituted, R2 represents H, a halogen atom, an S(O)zR3, -NHSO2R3, -NHSO2-phenyl or -NHSO2-(C1-C4) alkyl-phenyl group where z is equal to 0, 1 or 2 and R3 represents a (C1-C4)alkyl group, whereby phenyl can be optionally substituted; A is chosen from (see (II)), wherein n is equal to 0, 1 or 2, R4 and R5 represent H, a (C1-C4)alkyl, hydroxy, cyano, phenyl, benzyl, piperidyl, -CONH2, -CO-phenyl, -COOR3 -CH(phenyl)(OH) and -C(phenyl)2(OH) group or R4 and R5 form together an aromatic cycle with 6 chains which is optionally substituted, R6 represents H, a (C1-C4)alkyl, phenyl or benzyl group and B represents a homocycle or heterocycle which is nitrogenous with 5 or 6 chains and which is optionally fused with a phenyl group or which is optionally substituted. The invention also relates to the addition salts thereof, a method for the production and the use thereof in therapeutics.