发明名称 |
Therapy |
摘要 |
The invention concerns the use of a quinazoline derivative of Formula (I) wherein Q<1 >includes a quinazoline ring optionally substituted with a group such as halogeno, trifluoromethyl and cyano, or a group of the formula: Q<3>-X<1>- wherein X<1 >includes a direct bond and O and Q<3>includes aryl, aryl-(1-6C)alkyl, heterocyclyl and heterocyclyl-(1-6C)alkyl; each of R<2 >and R<3 >is hydrogen or (1-6C)alkyl; Z includes O, S and NH; and Q<2 >includes aryl and aryl-(1-3C)alkyl or a pharmaceutically-acceptable salt thereof, in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in a warm-blooded animal such as a human.
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申请公布号 |
US2003225111(A1) |
申请公布日期 |
2003.12.04 |
申请号 |
US20020220140 |
申请日期 |
2002.08.28 |
申请人 |
HENNEQUIN LAURENT FRANCOIS ANDRE;CRAWLEY GRAHAM CHARLES;MCKERRECHER DARREN;PLE PATRICK;POYSER JEFFREY PHILIP;LAMBERT CHRISTINE MARIE PAUL |
发明人 |
HENNEQUIN LAURENT FRANCOIS ANDRE;CRAWLEY GRAHAM CHARLES;MCKERRECHER DARREN;PLE PATRICK;POYSER JEFFREY PHILIP;LAMBERT CHRISTINE MARIE PAUL |
分类号 |
C07D239/94;A61K31/505;A61K31/517;A61K31/519;A61K31/5377;A61K31/541;A61P3/10;A61P9/00;A61P9/10;A61P13/12;A61P15/00;A61P17/06;A61P19/02;A61P27/02;A61P29/00;A61P35/00;A61P37/02;A61P43/00;C07D401/12;C07D403/12;C07D417/12;C07D487/04;C07D495/04;(IPC1-7):A61K31/519 |
主分类号 |
C07D239/94 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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