发明名称 |
Process for the preparation of L-lysine using coryneform bacteria which contain an attenuated malate enzyme gene |
摘要 |
The invention relates to a process for the preparation of L-amino acids, in which the following steps are carried out: a) fermentation of the coryneform bacteria which produce the desired L-amino acid and in which at least the gene which codes for the malate enzyme is attenuated, b) concentration of the desired L-amino acid in the medium or in the cells of the bacteria, and c) isolation of the L-amino acid, and optionally bacteria in which further genes of the biosynthesis pathway of the desired L-amino acid are additionally enhanced are employed, or bacteria in which the metabolic pathways which reduce the formation of the desired L-amino acid are at least partly eliminated are employed.
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申请公布号 |
EP1367130(A1) |
申请公布日期 |
2003.12.03 |
申请号 |
EP20030010869 |
申请日期 |
2003.05.15 |
申请人 |
DEGUSSA AG |
发明人 |
BATHE, BRIGITTE, DR.;FARWICK, MIKE, DR.;PFEFFERLE, WALTER, DR.;MARX, ACHIM, DR. |
分类号 |
C12P13/08;C12N1/21;C12P13/12;(IPC1-7):C12P13/06;C12P13/10;C12P13/14;C12P13/20;C12P13/22;C12P13/24 |
主分类号 |
C12P13/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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