| 发明名称 |
METHOD OF SYNTHESIZING PHOSPHOROTHIOATE OLIGONUCLEOTIDES |
| 摘要 |
This disclosure presents a method for the synthesis of phosphorothioate oligonucleotides using support-bound phosphoramidite intermediates. Phosphoramidite intermediates useful in the execution of the method described are also disclosed.
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| 申请公布号 |
CA2276213(C) |
申请公布日期 |
2003.12.02 |
| 申请号 |
CA19972276213 |
申请日期 |
1997.12.12 |
| 申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
RAVIKUMAR, VASULINGA;COLE, DOUGLAS L. |
| 分类号 |
C07H21/00;(IPC1-7):C07H21/00;C07H21/02;C07H21/04 |
主分类号 |
C07H21/00 |
| 代理机构 |
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