发明名称 |
HIV-specific T-cell induction |
摘要 |
This invention discloses diagnostic, preventative, and treatment therapies of AIDS involving determining whether a subject exhibits an HLA-Cw7-restricted CTL response. Some methods are directed to the use of HLA-Cw7 as a genetic marker for long-term non-progression and amenability to treatment therapies. Diagnostic methods include a method for predicting long term non-progression in an HIV-infected subject. Preventative and treatment methods encompass determining whether a subject exhibits or can exhibit an HLA-Cw7-restricted CTL response. They also encompass ways of eliciting such a response, if necessary. Furthermore, some of the methods involve administering one or more HIV polypeptides or peptides, or polynucleotides encoding them, as a treatment therapy to prevent the development of AIDS.
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申请公布号 |
US6656471(B1) |
申请公布日期 |
2003.12.02 |
申请号 |
US19990440772 |
申请日期 |
1999.11.16 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
SASTRY K. JAGANNADHA;ARLINGHAUS RALPH B.;NEHETE PRAMOD N. |
分类号 |
A61K31/513;A61K38/00;A61K39/00;A61K39/21;A61K39/385;A61K39/39;A61K45/00;A61K47/42;A61K47/48;A61P31/18;C07K14/16;C12N15/09;C12Q1/02;G01N33/50;G01N33/569;(IPC1-7):A61K38/00 |
主分类号 |
A61K31/513 |
代理机构 |
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主权项 |
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地址 |
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