发明名称 Epothilone derivatives
摘要 The present invention relates to compounds of the formula Q is selected from the group consisting of G is selected from the group consisting of alkyl, substituted alkyl, substituted or unsubstituted aryl, heterocyclo, W is O or NR15; X is O or H,H; Y is selected from the group consisting of O; H,OR16; OR17,OR17; NOR18; H,NOR19; H,NR20R21; H,H; or CHR22; OR17OR17 can be a cyclic ketal; Z1, and Z2 are selected from the group consisting of CH2, O, NR23, S, or SO2, wherein only one of Z and Z2 is a heteroatom; B1 and B2 are selected from the group consisting of OR24, or OCOR25, or O2CNR26R27; when B1 is H and Y is OH, H they can form a six-membered ring ketal or acetal; D is selected from the group consisting of NR28R29, NR30COR31 or saturated heterocycle R1, R2, R3, R4, R5, R6, R7, R13, R14, R18, R19, R20, R21, R22, R26, and R27 are selected from the group H, alkyl, substituted alkyl, or aryl and when R1 and R2 are alkyl can be joined to form a cycloalkyl; R3 and R4 are alkyl can be joined to form a cycloalkyl; R9, R10, R16, R17, R24, R25, and R31 are selected from the group H, alkyl, or substituted alkyl; R8, R11, R12, R28, R30, R32, R33, and R30 </su
申请公布号 US2003220295(A1) 申请公布日期 2003.11.27
申请号 US20030405886 申请日期 2003.04.03
申请人 VITE GREGORY D.;KIM SOONG-HOON;BORZILLERI ROBERT M.;JOHNSON JAMES A. 发明人 VITE GREGORY D.;KIM SOONG-HOON;BORZILLERI ROBERT M.;JOHNSON JAMES A.
分类号 C07D491/044;A61K31/335;A61K31/395;A61K31/427;A61P19/00;A61P35/00;A61P43/00;C07D225/00;C07D273/00;C07D277/26;C07D313/00;C07D417/06;C07D417/08;C07D491/04;C07D493/04;C07D498/04;(IPC1-7):A61K31/695;A01N55/00 主分类号 C07D491/044
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