DEVICE AND METHOD FOR DETECTING BIOELECTRIC SIGNALS FROM ELECTROPHYSIOLOGICALLY ACTIVE REGIONS IN SPHEROIDS

摘要

The invention relates to a device and a method for detecting bioelectric signals from spheroids. Said device comprises a measuring chamber having a wall enclosing a volume which is open on at least one side, consisting of non-electroconductive material, and comprising an inner cross-section at least in a measuring area, corresponding as far as possible to the largest cross-section of a spheroid. The inventive device also comprises at least a number of electrodes which are arranged in a common plane inside the wall of the measuring chamber, and each comprise one freely accessible electrode surface which is oriented towards the measuring area. Said device further comprises an impedance measuring system which is connected to the electrodes. The device and the method can be used in active ingredients tests on biological in vitro 3D (three-dimensional) cell agglomerates.