发明名称 |
SCYTOVIRINS AND RELATED CONJUGATES, FUSION PROTEINS, NUCLEIC ACIDS, VECTORS, HOST CELLS, COMPOSITIONS, ANTIBODIES AND METHODS OF USING SCYTOVIRINS |
摘要 |
An isolated or purified antiviral protein consisting essentially of the amino acid sequence of SEQ ID NO: 1, an amino acid sequence that is about 90% or more identical to SEQ ID NO: 1, an amino acid sequence that is about 90% or more homologous to SEQ ID NO: 1, or an antiviral fragment of any of the foregoing; a variant, fusion protein or conjugate thereof; a composition comprising (i) at least one of the foregoing and (ii) a carrier, excipient or adjuvant; an isolated or purified nucleic acid consisting essentially of a nucleotide sequence encoding the amino acid sequence of the aforementioned antiviral protein or antiviral fragment thereof, or a variant or fusion protein of either of the foregoing; an isolated cell comprising an above-described isolated or purified nucleic acid; a composition comprising (i) an above-described isolated or purified nucleic acid, and (ii) a carrier, excipient or adjuvant; a method of inhibiting a viral infection of a host comprising administering a viral infection-inhibiting amount of at least one of an above-described antiviral protein or an antiviral fragment thereof, a variant or fusion protein of either of the foregoing, an above-described nucleic acid, or an isolated cell comprising an abovedescribed nucleic acid; a method of inhibiting a virus in a biological sample or in/on an inanimate object comprising contacting the biological sample or the inanimate object with a viral-inhibiting amount of at least one of an above-described antiviral protein or an antiviral fragment thereof, or a variant, fusion protein or conjugate of either of the foregoing, antibodies and composition thereof, and a method of inhibiting infection of a mammal with a virus comprising administering to the mammal an anti-scytovirin antibody in an amount sufficient to induce in the mammal an immune response to the virus. |
申请公布号 |
WO03097814(A2) |
申请公布日期 |
2003.11.27 |
申请号 |
WO2003US15991 |
申请日期 |
2003.05.15 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES;BOYD, MICHAEL R.;BOKESCH, HEIDI R.;O'KEEFE, BARRY R.;MCKEE, TAWNYA C. |
发明人 |
BOYD, MICHAEL R.;BOKESCH, HEIDI R.;O'KEEFE, BARRY R.;MCKEE, TAWNYA C. |
分类号 |
A61K38/00;A61K39/12;C07K14/195;C07K14/435;C12P21/04 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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