发明名称 |
OIL-IN-WATER EMULSION OF l-MENTHOL |
摘要 |
Although an emulsion prepared by emulsifying l-menthol with an emulsifier alone remains stable within several hours after the preparation, l-menthol therein is then gradually separated out and migrates towards the surface. As l-menthol is separated out from the emulsion as described above, the component distribution in the emulsion becomes uneven. When such an emulsion is sprayed as a peristalsis controller onto, for example, the stomach wall, no constant effect can be achieved and, therefore, it is required to prepare the emulsion immediately before using. An oil-in-water emulsion of l-menthol which remains stable without suffering from the separation of l-menthol can be obtained by mixing l-menthol with a fatty acid, a fatty acid ester or a mixture thereof, an emulsifier and water and then emulsifying. When directly sprayed to, for example, the inside of a digestive tract, this emulsion immediately and continuously exhibits its effect of controlling the peristalsis. It can be safely used for a subject under contraindications for the use of scopolamine butyl bromide, for example, a patient with glaucoma.
|
申请公布号 |
WO03097027(A1) |
申请公布日期 |
2003.11.27 |
申请号 |
WO2003JP06305 |
申请日期 |
2003.05.20 |
申请人 |
NIHON PHARMACEUTICAL CO., LTD.;KATAOKA, YOSUKE;HAMAWAKI, TOMONORI;ISODA, TAKAKO;HIKI, NAOKI |
发明人 |
KATAOKA, YOSUKE;HAMAWAKI, TOMONORI;ISODA, TAKAKO;HIKI, NAOKI |
分类号 |
A61K9/107;A61K31/045;A61K49/00;A61P1/00;A61P43/00;(IPC1-7):A61K31/045;A61K47/12;A61K47/14;A61K47/26;A61K47/34;A61K47/44 |
主分类号 |
A61K9/107 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|