Compounds, pharmaceutical compositions, and methods for inhibiting cyclin-dependent kinases

摘要

Pharmaceutical compositions containing effective amounts of CDK-inhibiting diaminothiazole compounds of the following formula (where R<1 >and R<2 >are as defined in the specification) or their salts, or prodrugs or active metabolites of such compounds or salts, are useful for treating disorders and diseases such as cancer: In preferred embodiments, R<1 >and R<2 >are independently unsubstituted or substituted carbocyclic or heterocyclic aryl ring structures. Compounds where R<2 >is ortho-substituted aryl are especially potent inhibitors of CDKs such as CDK4.