摘要 |
The present invention provides 1,3-dioxolane and 1,3-oxathiolane derivatives that are inhibitors of RNA-dependent RNA viral polymerase. These compounds are also inhibitors of RNA-dependent RNA viral replication and are useful in the treatment of RNA-dependent RNA viral infection. The invention also describes pharmaceutical compositions containing such 1,3-dioxolane and 1,3-oxathiolane derivatives alone or in combination with other agents active against RNA-dependent RNA viral infection. Also disclosed are methods of inhibiting RNA-dependent RNA viral polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the compounds of the present invention. |
申请人 |
MERCK & CO., INC.;ISIS PHARMACEUTICALS, INC.;CARROLL, STEVEN, S.;MACCOSS, MALCOLM;KUO, LAWRENCE, C.;OLSEN, DAVID, B.;BHAT, BALKRISHEN;ELDRUP, ANNE BETTINA;PRHAVC, MARIJA;MALIK, LEILA;BERA, SANJIB |
发明人 |
CARROLL, STEVEN, S.;MACCOSS, MALCOLM;KUO, LAWRENCE, C.;OLSEN, DAVID, B.;BHAT, BALKRISHEN;ELDRUP, ANNE BETTINA;PRHAVC, MARIJA;MALIK, LEILA;BERA, SANJIB |