USE OF GAL3 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF DEPRESSION AND/OR ANXIETY AND COMPOUNDS USEFUL IN SUCH METHODS
摘要
This invention is directed to pyrimidine and indolone derivatives which are selective antagonists for the GAL3 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of a compound of the invention effective to treat the subject's depression and/or anxiety. This invention also provides a method of treating depression and/or anxiety in a subject which comprises administering to the subject a composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a GAL3 receptor antagonist.
申请公布号
EP1363638(A2)
申请公布日期
2003.11.26
申请号
EP20020714918
申请日期
2002.01.31
申请人
SYNAPTIC PHARMACEUTICAL CORPORATION
发明人
BLACKBURN, THOMAS P.;KONKEL, MICHAEL;BOTEJU, LAKMAL W.;TALISMAN, IAN JAMIE;WETZEL, JOHN M.;PACKIARAJAN, MATHIVANAN;CHEN, HEIDI;JIMENEZ, HERMO;LAGU, BHARAT;LIM, KITAE;NOBLE, STEWART