GLYCOPYRANOSYLOXYPYRAZOLE DERIVATIVES AND MEDICINAL USE THEREOF

摘要

The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R<1>, R<2> and R<3> represent a hydrogen atom or a halogen atom; R<4> represents a lower alkyl group or a halo(lower alkyl) group; and R<5> represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, etc., a pharmaceutically acceptable salt thereof or a prodrug thereof., which exert an excellent inhibitory activity in human SGLT2, and therefore are useful as drugs for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, pharmaceutically acceptable salts thereof or prodrugs thereof, production intermediates thereof and pharmaceutical uses thereof.