| 摘要 |
The present invention relates to a pharmaceutical composition containing a compound represented by the formula: wherein R is an aliphatic hydrocarbon group, an aromatic hydrocarbon group, a heterocyclic group, a group represented by the formula: -OR<1 >(wherein R<1 >is H or an aliphatic hydrocarbon group) or a group represented by the formula -N(R<1b>)(R<1c>) (wherein R<1b >is H or an aliphatic hydrocarbon group and R<1c >is H or an aliphatic hydrocarbon group), R<0 >is H or an aliphatic hydrocarbon group, or R and R<0 >in combination represent a bond, ring A<1 >is a cycloalkene optionally substituted by 1 to 4 substituents selected from (1) an aliphatic hydrocarbon group, (2) an aromatic hydrocarbon group, (3) a group represented by the formula: -OR<1 >(wherein R<1 >is as defined above) and (4) a halogen atom, Ar is an aromatic hydrocarbon group optionally having substituents, a group represented by the formula: represents a group represented by the formula: and n is an integer of 1 to 4, a salt thereof or a prodrug thereof, and a nonionic surfactant and/or a cyclodextrin derivative readily soluble in water, and a method for improving solubility, stability or coloring property of the compound, a salt thereof or a prodrug thereof.
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