发明名称 |
Trioxane derivatives |
摘要 |
This invention relates to compounds containing a trioxane moiety, especially certain artemisinin derivatives, which have cytotoxic and antitumour activity and their use in the treatment of cancer. Some of these compounds comprise a ligand which is capable of binding to a nucleic acid and a group containing a trioxane moiety which is capable of acting as source of free radicals which are capable of chemically interacting with a nucleic acid. Processes for the preparation of such compounds and pharmaceutical compositions containing such compounds are also provided.
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申请公布号 |
US6649647(B1) |
申请公布日期 |
2003.11.18 |
申请号 |
US20020743860 |
申请日期 |
2002.04.15 |
申请人 |
HAYNES RICHARD;CHAN HO-WAI;LAM WAI-LUN;TSANG HING-WO;HSIAO WEN-LUAN;LERCHEN HANS-GEORG;BAUMGARTEN JOERG |
发明人 |
HAYNES RICHARD;CHAN HO-WAI;LAM WAI-LUN;TSANG HING-WO;HSIAO WEN-LUAN;LERCHEN HANS-GEORG;BAUMGARTEN JOERG |
分类号 |
C07D491/20;C07D493/20;(IPC1-7):A61K31/357;C07D493/12 |
主分类号 |
C07D491/20 |
代理机构 |
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地址 |
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