| 摘要 |
<p>This invention relates to sulphonated dehydrogenated sylvate, a kind of new salt useful in treating digestive canal ulcer, acute & chronic gastritis and erosive gastritis etc., as well as its preparation and use. Said compound can be represented by formula (1), in which R is Bi (OH)++, Zn++, 2BiO or 1/2Zn H. Its preparation comprises: (a) sequentially treating the industrically calcinated calcium sylvate with acid, base and extracting with organic solvent to give sylvic acid with less isomer; (b) reacting said sylvic acid with Pd/C to provide dehydrogenated sylvic acid, then converting it to pure sulphonated product, i.e. sulphonated dehydrogenated sylvic acid via sulphonation and recrystallization; (c) by use of neutralization or salt displacement reaction to convert the sulphonated product of step (b) to monozinc or bismuth salt of sulphonated dehydrogenated sylvic acid. The resultant salt can be used to prepare medicine of treating digestive canal ulcer and gastritis.</p> |
