| 摘要 |
<p>It is intended to provide a cell fusion type vector having replicability with modified protease-dependent tropism. An M gene knockout virus vector encoding a modified F protein, in which the cleavage site of a paramyxovirus F protein has been modified into a sequence cleaved by another protease, is produced. When transferred into cells, this vector replicates genomic RNA carried thereby and thus extends the cell fusion type infection toward adjacent cells depending on the latter protease as described above but does not release any viral particles. Such a vector encoding an F protein cleaved by a protease the activity of which is enhanced due to cancer shows an effect of inhibiting caner growth in vivo.</p> |
