METHOD TO IDENTIFY MODULATORS FOR HUMAN 3 alpha -HYDROXYSTEROID DEHYDROGENASE
摘要
3 alpha -hydroxysteroid dehydrogenase (3a-HSD) plays a central role in the metabolism and action of steroid hormones and neurosteroids (steroids synthesized in the central nervous system). The high resolution structure of human type III 3a-HSD crystallized in complex with cofactor NADP is determined by X-ray diffraction. Furthermore the active site is determined. The structure coordinates of the enzyme may be used to design and select novel classes of modulators to human type III 3a-HSD.
申请公布号
WO03018830(A3)
申请公布日期
2003.11.13
申请号
WO2002EP09366
申请日期
2002.08.21
申请人
NOVARTIS AG;NOVARTIS PHARMA GMBH;FLOERSHEIM, PHILIPP;OSTERMEIER, CHRISTIAN;UZUNOV, DONCHO;JAHNKE, WOLFGANG
发明人
FLOERSHEIM, PHILIPP;OSTERMEIER, CHRISTIAN;UZUNOV, DONCHO;JAHNKE, WOLFGANG