| 摘要 |
The invention relates to a method for the integrated separation of one or mo re organic substances present in an aqueous bio-process mixture containing at least one positively charged and/or chargeable group containing nitrogen by means of reactive extraction in at least one step. According to the inventio n, at least one liquid-liquid centrifuge is used for said reactive extraction a nd the organic substances from the extraction agent are re-extracted into an aqueous phase. In particular, cells and protein are removed from the bio- process mixture that is fed to the liquid-liquid centrifuges before said mixture is fed to the first centrifuge. The invention also relates to a meth od of this type, whereby an aqueous bio-process mixture is continuously removed from a bio-reactor, fed, together with an extraction agent, to a liquid-liqu id centrifuge, extracted by means of the extraction agent, thus obtaining an organic phase, which contains the substance to be extracted. The substance c an be re-extracted in a circuit using a second liquid-liquid centrifuge, producing a concentrated aqueous solution from the extracted substance and t he organic phase is returned to the first liquid-liquid centrifuge.
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