发明名称 |
AMINE FUNCTIONALIZED SUPERPARAMAGNETIC NANOPARTICLES FOR THE SYNTHESIS OF BIOCONJUGATES AND USES THEREFOR |
摘要 |
Amine functionalized magnetic nanoparticle compositions and processes for synthesizing the same are described. The process consists of obtaining a carboxylated polymer in substantially pure form, which is used to prepare a substantially size homogeneous, polymer coated carboxyl, functionalized magnetic nanoparticle. The carboxyl groups are converted to reactive primary amino groups by the use of a water-soluble carbodiimide followed by reaction of a large excess of a diamine. The amine-terminated nanoparticles are then reacted with bifunctional crosslinking agents and with various biomolecules to make nanoparticles for in vitro assays, cell sorting applications and target specific MR contrast agents. |
申请公布号 |
WO03057175(A3) |
申请公布日期 |
2003.11.13 |
申请号 |
WO2003US00051 |
申请日期 |
2003.01.02 |
申请人 |
VISEN MEDICAL, INC.;GAW, DEBRA, A.;JOSEPHSON, LEE |
发明人 |
GAW, DEBRA, A.;JOSEPHSON, LEE |
分类号 |
A61K9/50;A61K47/48 |
主分类号 |
A61K9/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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