OLIGOPEPTIDE SPECIFICALLY BINDING TO SCHWANN CELLS
摘要
PURPOSE: An oligopeptide specifically binding to Schwann cells is provided, which is useful for treatment of damage in nerve cells. CONSTITUTION: An oligopeptide specifically binding to Schwann cells is provided, wherein the oligopeptide has the amino acid sequence of SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3. The oligopeptide specifically binding to Schwann cell is isolated by inserting random amino acid sequences into a vector pFLITRIX containing the active portion of thioredoxin; transforming Escherichia coli with the vector pFLITRIX; culturing the transformed E. coli in an ampicillin containing IMC selection medium; adding tryptophane into the medium and culturing it to induce FLITRIX peptide; binding the transformed E. coli to Schwann cells fixed on a dish; selecting peptides specifically binding to the Schwann cells; and sequencing the selected peptides.
申请公布号
KR20030086778(A)
申请公布日期
2003.11.12
申请号
KR20020024943
申请日期
2002.05.07
申请人
CHONG, JONG PYONG;CHOUNG, PILL HOON;JANG, JUN HYEOG;SEO, BYOUNG MOO
发明人
CHONG, JONG PYONG;CHOUNG, PILL HOON;JANG, JUN HYEOG;SEO, BYOUNG MOO